BDBM348136 US9790228, Compound 55

SMILES: Nc1ncnc2n(Cc3cc4ccccc4nc3-c3cccnc3)nc(-c3cc(O)cc(F)c3)c12

InChI Key: InChIKey=QWDTXCUJIUIOIO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 348136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM348136 (US9790228, Compound 55) Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3-c3cccnc3)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C26H18FN7O/c27-19-9-17(10-20(35)11-19)24-22-25(28)30-14-31-26(22)34(33-24)13-18-8-15-4-1-2-6-21(15)32-23(18)16-5-3-7-29-12-16/h1-12,14,35H,13H2,(H2,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM348136 (US9790228, Compound 55) Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3-c3cccnc3)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C26H18FN7O/c27-19-9-17(10-20(35)11-19)24-22-25(28)30-14-31-26(22)34(33-24)13-18-8-15-4-1-2-6-21(15)32-23(18)16-5-3-7-29-12-16/h1-12,14,35H,13H2,(H2,28,30,31)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
PI3-kinase class I (Homo sapiens (Human))	BDBM348136 (US9790228, Compound 55) Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3-c3cccnc3)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C26H18FN7O/c27-19-9-17(10-20(35)11-19)24-22-25(28)30-14-31-26(22)34(33-24)13-18-8-15-4-1-2-6-21(15)32-23(18)16-5-3-7-29-12-16/h1-12,14,35H,13H2,(H2,28,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM348136 (US9790228, Compound 55) Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3-c3cccnc3)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C26H18FN7O/c27-19-9-17(10-20(35)11-19)24-22-25(28)30-14-31-26(22)34(33-24)13-18-8-15-4-1-2-6-21(15)32-23(18)16-5-3-7-29-12-16/h1-12,14,35H,13H2,(H2,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair