BDBM348657 N-[4-[(1S,3R,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-3-yl]phenyl]-5-(trifluoromethyl)pyridin-2-amine::US9790230, Example 19

SMILES: FC(F)(F)c1ccc(Nc2ccc(cc2)[C@H]2O[C@@H]3CN[C@H]2C3)nc1

InChI Key: InChIKey=NDTAGOCAPXVPNO-OFQRWUPVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 348657   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Trace amine-associated receptor 1 (Rattus norvegicus (Rat))	BDBM348657 (N-[4-[(1S,3R,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-3...) Show SMILES FC(F)(F)c1ccc(Nc2ccc(cc2)[C@H]2O[C@@H]3CN[C@H]2C3)nc1 |r| Show InChI InChI=1S/C17H16F3N3O/c18-17(19,20)11-3-6-15(22-8-11)23-12-4-1-10(2-5-12)16-14-7-13(24-16)9-21-14/h1-6,8,13-14,16,21H,7,9H2,(H,22,23)/t13-,14-,16+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64.1	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...				US Patent US9790230 (2017) BindingDB Entry DOI: 10.7270/Q2XG9T8R
					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1) (Mus musculus (Mouse))	BDBM348657 (N-[4-[(1S,3R,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-3...) Show SMILES FC(F)(F)c1ccc(Nc2ccc(cc2)[C@H]2O[C@@H]3CN[C@H]2C3)nc1 |r| Show InChI InChI=1S/C17H16F3N3O/c18-17(19,20)11-3-6-15(22-8-11)23-12-4-1-10(2-5-12)16-14-7-13(24-16)9-21-14/h1-6,8,13-14,16,21H,7,9H2,(H,22,23)/t13-,14-,16+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...				US Patent US9790230 (2017) BindingDB Entry DOI: 10.7270/Q2XG9T8R
					More data for this Ligand-Target Pair