null

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1

InChI Key: InChIKey=NCHRMJWKKXNHAK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350024   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM350024 (US10208024, Example 23 | US10766881, Example 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1 |(4.62,3.85,;5.96,3.08,;5.96,1.54,;7.29,.77,;7.29,-.77,;8.62,-1.54,;8.62,-3.08,;5.96,-1.54,;5.96,-3.08,;4.62,-.77,;4.62,.77,;3.29,1.54,;3.29,-1.54,;1.95,-.77,;.62,-1.54,;.62,-3.08,;1.95,-3.85,;3.29,-3.08,;4.62,-3.85,;-.71,-.77,;-2.05,-1.54,;-3.38,-.77,;-3.38,.77,;-2.05,1.54,;-.71,.77,;.62,1.54,;-4.71,-1.54,;-4.71,-3.08,;-6.18,-3.56,;-7.08,-2.31,;-8.62,-2.31,;-6.18,-1.06,)| Show InChI InChI=1S/C20H17Cl2N7O3/c1-28-9-10(7-25-28)12-8-24-20(23)18(26-12)11-4-5-15(30)29(27-11)19-16(21)13(31-2)6-14(32-3)17(19)22/h4-9H,1-3H3,(H2,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM350024 (US10208024, Example 23 | US10766881, Example 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1 |(4.62,3.85,;5.96,3.08,;5.96,1.54,;7.29,.77,;7.29,-.77,;8.62,-1.54,;8.62,-3.08,;5.96,-1.54,;5.96,-3.08,;4.62,-.77,;4.62,.77,;3.29,1.54,;3.29,-1.54,;1.95,-.77,;.62,-1.54,;.62,-3.08,;1.95,-3.85,;3.29,-3.08,;4.62,-3.85,;-.71,-.77,;-2.05,-1.54,;-3.38,-.77,;-3.38,.77,;-2.05,1.54,;-.71,.77,;.62,1.54,;-4.71,-1.54,;-4.71,-3.08,;-6.18,-3.56,;-7.08,-2.31,;-8.62,-2.31,;-6.18,-1.06,)| Show InChI InChI=1S/C20H17Cl2N7O3/c1-28-9-10(7-25-28)12-8-24-20(23)18(26-12)11-4-5-15(30)29(27-11)19-16(21)13(31-2)6-14(32-3)17(19)22/h4-9H,1-3H3,(H2,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 [397-806] (Homo sapiens (Human))	BDBM350024 (US10208024, Example 23 | US10766881, Example 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1 |(4.62,3.85,;5.96,3.08,;5.96,1.54,;7.29,.77,;7.29,-.77,;8.62,-1.54,;8.62,-3.08,;5.96,-1.54,;5.96,-3.08,;4.62,-.77,;4.62,.77,;3.29,1.54,;3.29,-1.54,;1.95,-.77,;.62,-1.54,;.62,-3.08,;1.95,-3.85,;3.29,-3.08,;4.62,-3.85,;-.71,-.77,;-2.05,-1.54,;-3.38,-.77,;-3.38,.77,;-2.05,1.54,;-.71,.77,;.62,1.54,;-4.71,-1.54,;-4.71,-3.08,;-6.18,-3.56,;-7.08,-2.31,;-8.62,-2.31,;-6.18,-1.06,)| Show InChI InChI=1S/C20H17Cl2N7O3/c1-28-9-10(7-25-28)12-8-24-20(23)18(26-12)11-4-5-15(30)29(27-11)19-16(21)13(31-2)6-14(32-3)17(19)22/h4-9H,1-3H3,(H2,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 [308-731] (Homo sapiens (Human))	BDBM350024 (US10208024, Example 23 | US10766881, Example 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1 |(4.62,3.85,;5.96,3.08,;5.96,1.54,;7.29,.77,;7.29,-.77,;8.62,-1.54,;8.62,-3.08,;5.96,-1.54,;5.96,-3.08,;4.62,-.77,;4.62,.77,;3.29,1.54,;3.29,-1.54,;1.95,-.77,;.62,-1.54,;.62,-3.08,;1.95,-3.85,;3.29,-3.08,;4.62,-3.85,;-.71,-.77,;-2.05,-1.54,;-3.38,-.77,;-3.38,.77,;-2.05,1.54,;-.71,.77,;.62,1.54,;-4.71,-1.54,;-4.71,-3.08,;-6.18,-3.56,;-7.08,-2.31,;-8.62,-2.31,;-6.18,-1.06,)| Show InChI InChI=1S/C20H17Cl2N7O3/c1-28-9-10(7-25-28)12-8-24-20(23)18(26-12)11-4-5-15(30)29(27-11)19-16(21)13(31-2)6-14(32-3)17(19)22/h4-9H,1-3H3,(H2,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...				US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 [403-822] (Homo sapiens (Human))	BDBM350024 (US10208024, Example 23 | US10766881, Example 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1 |(4.62,3.85,;5.96,3.08,;5.96,1.54,;7.29,.77,;7.29,-.77,;8.62,-1.54,;8.62,-3.08,;5.96,-1.54,;5.96,-3.08,;4.62,-.77,;4.62,.77,;3.29,1.54,;3.29,-1.54,;1.95,-.77,;.62,-1.54,;.62,-3.08,;1.95,-3.85,;3.29,-3.08,;4.62,-3.85,;-.71,-.77,;-2.05,-1.54,;-3.38,-.77,;-3.38,.77,;-2.05,1.54,;-.71,.77,;.62,1.54,;-4.71,-1.54,;-4.71,-3.08,;-6.18,-3.56,;-7.08,-2.31,;-8.62,-2.31,;-6.18,-1.06,)| Show InChI InChI=1S/C20H17Cl2N7O3/c1-28-9-10(7-25-28)12-8-24-20(23)18(26-12)11-4-5-15(30)29(27-11)19-16(21)13(31-2)6-14(32-3)17(19)22/h4-9H,1-3H3,(H2,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM350024 (US10208024, Example 23 | US10766881, Example 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1 |(4.62,3.85,;5.96,3.08,;5.96,1.54,;7.29,.77,;7.29,-.77,;8.62,-1.54,;8.62,-3.08,;5.96,-1.54,;5.96,-3.08,;4.62,-.77,;4.62,.77,;3.29,1.54,;3.29,-1.54,;1.95,-.77,;.62,-1.54,;.62,-3.08,;1.95,-3.85,;3.29,-3.08,;4.62,-3.85,;-.71,-.77,;-2.05,-1.54,;-3.38,-.77,;-3.38,.77,;-2.05,1.54,;-.71,.77,;.62,1.54,;-4.71,-1.54,;-4.71,-3.08,;-6.18,-3.56,;-7.08,-2.31,;-8.62,-2.31,;-6.18,-1.06,)| Show InChI InChI=1S/C20H17Cl2N7O3/c1-28-9-10(7-25-28)12-8-24-20(23)18(26-12)11-4-5-15(30)29(27-11)19-16(21)13(31-2)6-14(32-3)17(19)22/h4-9H,1-3H3,(H2,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair