BDBM350034 US10208024, Example 33::US10766881, Example 33

SMILES: COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1

InChI Key: InChIKey=BINZKUIUUZZJSK-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM350034 (US10208024, Example 33 | US10766881, Example 33) Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H32N8O4/c1-37-11-10-33-8-6-19(7-9-33)34-17-18(15-30-34)24-16-29-27(28)26(31-24)23-4-5-25(36)35(32-23)20-12-21(38-2)14-22(13-20)39-3/h4-5,12-17,19H,6-11H2,1-3H3,(H2,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.6	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM350034 (US10208024, Example 33 | US10766881, Example 33) Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H32N8O4/c1-37-11-10-33-8-6-19(7-9-33)34-17-18(15-30-34)24-16-29-27(28)26(31-24)23-4-5-25(36)35(32-23)20-12-21(38-2)14-22(13-20)39-3/h4-5,12-17,19H,6-11H2,1-3H3,(H2,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) (Homo sapiens (Human))	BDBM350034 (US10208024, Example 33 | US10766881, Example 33) Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H32N8O4/c1-37-11-10-33-8-6-19(7-9-33)34-17-18(15-30-34)24-16-29-27(28)26(31-24)23-4-5-25(36)35(32-23)20-12-21(38-2)14-22(13-20)39-3/h4-5,12-17,19H,6-11H2,1-3H3,(H2,28,29)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731) (Homo sapiens (Human))	BDBM350034 (US10208024, Example 33 | US10766881, Example 33) Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H32N8O4/c1-37-11-10-33-8-6-19(7-9-33)34-17-18(15-30-34)24-16-29-27(28)26(31-24)23-4-5-25(36)35(32-23)20-12-21(38-2)14-22(13-20)39-3/h4-5,12-17,19H,6-11H2,1-3H3,(H2,28,29)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.6	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...				US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822) (Homo sapiens (Human))	BDBM350034 (US10208024, Example 33 | US10766881, Example 33) Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H32N8O4/c1-37-11-10-33-8-6-19(7-9-33)34-17-18(15-30-34)24-16-29-27(28)26(31-24)23-4-5-25(36)35(32-23)20-12-21(38-2)14-22(13-20)39-3/h4-5,12-17,19H,6-11H2,1-3H3,(H2,28,29)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM350034 (US10208024, Example 33 | US10766881, Example 33) Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H32N8O4/c1-37-11-10-33-8-6-19(7-9-33)34-17-18(15-30-34)24-16-29-27(28)26(31-24)23-4-5-25(36)35(32-23)20-12-21(38-2)14-22(13-20)39-3/h4-5,12-17,19H,6-11H2,1-3H3,(H2,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair