null

SMILES: COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1

InChI Key: InChIKey=COMXNOYVEFLSSH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350035   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM350035 (US10208024, Example 34 | US10766881, Example 34) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1 Show InChI InChI=1S/C27H29F3N8O4/c1-40-20-11-19(12-21(13-20)41-2)38-24(39)4-3-22(35-38)25-26(31)32-15-23(34-25)17-14-33-37(16-17)18-5-7-36(8-6-18)9-10-42-27(28,29)30/h3-4,11-16,18H,5-10H2,1-2H3,(H2,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38.4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM350035 (US10208024, Example 34 | US10766881, Example 34) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1 Show InChI InChI=1S/C27H29F3N8O4/c1-40-20-11-19(12-21(13-20)41-2)38-24(39)4-3-22(35-38)25-26(31)32-15-23(34-25)17-14-33-37(16-17)18-5-7-36(8-6-18)9-10-42-27(28,29)30/h3-4,11-16,18H,5-10H2,1-2H3,(H2,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 [397-806] (Homo sapiens (Human))	BDBM350035 (US10208024, Example 34 | US10766881, Example 34) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1 Show InChI InChI=1S/C27H29F3N8O4/c1-40-20-11-19(12-21(13-20)41-2)38-24(39)4-3-22(35-38)25-26(31)32-15-23(34-25)17-14-33-37(16-17)18-5-7-36(8-6-18)9-10-42-27(28,29)30/h3-4,11-16,18H,5-10H2,1-2H3,(H2,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 [308-731] (Homo sapiens (Human))	BDBM350035 (US10208024, Example 34 | US10766881, Example 34) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1 Show InChI InChI=1S/C27H29F3N8O4/c1-40-20-11-19(12-21(13-20)41-2)38-24(39)4-3-22(35-38)25-26(31)32-15-23(34-25)17-14-33-37(16-17)18-5-7-36(8-6-18)9-10-42-27(28,29)30/h3-4,11-16,18H,5-10H2,1-2H3,(H2,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38.4	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...				US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 [403-822] (Homo sapiens (Human))	BDBM350035 (US10208024, Example 34 | US10766881, Example 34) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1 Show InChI InChI=1S/C27H29F3N8O4/c1-40-20-11-19(12-21(13-20)41-2)38-24(39)4-3-22(35-38)25-26(31)32-15-23(34-25)17-14-33-37(16-17)18-5-7-36(8-6-18)9-10-42-27(28,29)30/h3-4,11-16,18H,5-10H2,1-2H3,(H2,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM350035 (US10208024, Example 34 | US10766881, Example 34) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(CCOC(F)(F)F)CC1 Show InChI InChI=1S/C27H29F3N8O4/c1-40-20-11-19(12-21(13-20)41-2)38-24(39)4-3-22(35-38)25-26(31)32-15-23(34-25)17-14-33-37(16-17)18-5-7-36(8-6-18)9-10-42-27(28,29)30/h3-4,11-16,18H,5-10H2,1-2H3,(H2,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair