Found 6 hits for monomerid = 350059 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM350059
(US10208024, Example 58 | US10766881, Example 58)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 |(6.08,3.85,;7.42,3.08,;7.42,1.54,;8.75,.77,;8.75,-.77,;10.08,-1.54,;10.08,-3.08,;7.42,-1.54,;7.42,-3.08,;6.08,-.77,;6.08,.77,;4.75,1.54,;4.75,-1.54,;3.42,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;.75,-.77,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-.58,1.54,;.75,.77,;2.08,1.54,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-4.72,-1.06,;-7.11,-1.91,;-7.51,-.42,;-9,-.03,;-10.08,-1.11,;-9.69,-2.6,;-8.2,-3,)| Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM350059
(US10208024, Example 58 | US10766881, Example 58)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 |(6.08,3.85,;7.42,3.08,;7.42,1.54,;8.75,.77,;8.75,-.77,;10.08,-1.54,;10.08,-3.08,;7.42,-1.54,;7.42,-3.08,;6.08,-.77,;6.08,.77,;4.75,1.54,;4.75,-1.54,;3.42,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;.75,-.77,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-.58,1.54,;.75,.77,;2.08,1.54,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-4.72,-1.06,;-7.11,-1.91,;-7.51,-.42,;-9,-.03,;-10.08,-1.11,;-9.69,-2.6,;-8.2,-3,)| Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806)
(Homo sapiens (Human)) | BDBM350059
(US10208024, Example 58 | US10766881, Example 58)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 |(6.08,3.85,;7.42,3.08,;7.42,1.54,;8.75,.77,;8.75,-.77,;10.08,-1.54,;10.08,-3.08,;7.42,-1.54,;7.42,-3.08,;6.08,-.77,;6.08,.77,;4.75,1.54,;4.75,-1.54,;3.42,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;.75,-.77,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-.58,1.54,;.75,.77,;2.08,1.54,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-4.72,-1.06,;-7.11,-1.91,;-7.51,-.42,;-9,-.03,;-10.08,-1.11,;-9.69,-2.6,;-8.2,-3,)| Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| |
US Patent US10766881 (2020)
|
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)
(Homo sapiens (Human)) | BDBM350059
(US10208024, Example 58 | US10766881, Example 58)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 |(6.08,3.85,;7.42,3.08,;7.42,1.54,;8.75,.77,;8.75,-.77,;10.08,-1.54,;10.08,-3.08,;7.42,-1.54,;7.42,-3.08,;6.08,-.77,;6.08,.77,;4.75,1.54,;4.75,-1.54,;3.42,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;.75,-.77,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-.58,1.54,;.75,.77,;2.08,1.54,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-4.72,-1.06,;-7.11,-1.91,;-7.51,-.42,;-9,-.03,;-10.08,-1.11,;-9.69,-2.6,;-8.2,-3,)| Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| Assay Description
To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660... |
US Patent US10766881 (2020)
|
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2 (FGFR2)(403-822)
(Homo sapiens (Human)) | BDBM350059
(US10208024, Example 58 | US10766881, Example 58)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 |(6.08,3.85,;7.42,3.08,;7.42,1.54,;8.75,.77,;8.75,-.77,;10.08,-1.54,;10.08,-3.08,;7.42,-1.54,;7.42,-3.08,;6.08,-.77,;6.08,.77,;4.75,1.54,;4.75,-1.54,;3.42,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;.75,-.77,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-.58,1.54,;.75,.77,;2.08,1.54,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-4.72,-1.06,;-7.11,-1.91,;-7.51,-.42,;-9,-.03,;-10.08,-1.11,;-9.69,-2.6,;-8.2,-3,)| Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| |
US Patent US10766881 (2020)
|
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM350059
(US10208024, Example 58 | US10766881, Example 58)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 |(6.08,3.85,;7.42,3.08,;7.42,1.54,;8.75,.77,;8.75,-.77,;10.08,-1.54,;10.08,-3.08,;7.42,-1.54,;7.42,-3.08,;6.08,-.77,;6.08,.77,;4.75,1.54,;4.75,-1.54,;3.42,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;.75,-.77,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-.58,1.54,;.75,.77,;2.08,1.54,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-4.72,-1.06,;-7.11,-1.91,;-7.51,-.42,;-9,-.03,;-10.08,-1.11,;-9.69,-2.6,;-8.2,-3,)| Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
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