Found 6 hits for monomerid = 350083 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM350083
(US10208024, Example 82 | US10766881, Example 82)Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)| Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM350083
(US10208024, Example 82 | US10766881, Example 82)Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)| Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806)
(Homo sapiens (Human)) | BDBM350083
(US10208024, Example 82 | US10766881, Example 82)Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)| Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| |
US Patent US10766881 (2020)
|
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)
(Homo sapiens (Human)) | BDBM350083
(US10208024, Example 82 | US10766881, Example 82)Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)| Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| Assay Description
To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660... |
US Patent US10766881 (2020)
|
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2 (FGFR2)(403-822)
(Homo sapiens (Human)) | BDBM350083
(US10208024, Example 82 | US10766881, Example 82)Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)| Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| |
US Patent US10766881 (2020)
|
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM350083
(US10208024, Example 82 | US10766881, Example 82)Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)| Show InChI InChI=1S/C27H30F2N8O4/c1-39-11-10-35-8-6-17(7-9-35)36-15-16(13-32-36)19-14-31-27(30)25(33-19)18-4-5-22(38)37(34-18)26-23(28)20(40-2)12-21(41-3)24(26)29/h4-5,12-15,17H,6-11H2,1-3H3,(H2,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
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