BDBM351259 5-Fluoro-1-methyl-6-[4-[[1-(1-methylpyrazole-4-carbonyl)piperidin-4-yl]methyl]-1H-pyrazol-3-yl]-3,4-dihydroquinolin-2-one::US9796702, 20::US9796702, 27
SMILES: CN1C(=O)CCc2c(F)c(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1cnn(C)c1
InChI Key: InChIKey=YZJBSCRWRHBKRY-UHFFFAOYSA-N
Data: 4 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human)) | BDBM351259 (5-Fluoro-1-methyl-6-[4-[[1-(1-methylpyrazole-4-car...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.00500 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita... | US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 11B1 (Homo sapiens (Human)) | BDBM351259 (5-Fluoro-1-methyl-6-[4-[[1-(1-methylpyrazole-4-car...) | PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.499 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita... | US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human)) | BDBM351259 (5-Fluoro-1-methyl-6-[4-[[1-(1-methylpyrazole-4-car...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.00200 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita... | US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 11B1 (Homo sapiens (Human)) | BDBM351259 (5-Fluoro-1-methyl-6-[4-[[1-(1-methylpyrazole-4-car...) | PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.723 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita... | US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G | |||||||||||
More data for this Ligand-Target Pair |