BDBM351277 (+)-6-[4-[(1R)-1-(1-acetylpiperidin-4-yl)ethyl]-1H-pyrazol-3-yl]-5-fluoro-1-methyl-3,4-dihydroquinolin-2-one::US9796702, 38
SMILES: C[C@H](C1CCN(CC1)C(C)=O)c1c[nH]nc1-c1ccc2N(C)C(=O)CCc2c1F
InChI Key: InChIKey=HUVLJWOWKSCYTO-CYBMUJFWSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 11B1 (Homo sapiens (Human)) | BDBM351277 ((+)-6-[4-[(1R)-1-(1-acetylpiperidin-4-yl)ethyl]-1H...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0740 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita... | US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human)) | BDBM351277 ((+)-6-[4-[(1R)-1-(1-acetylpiperidin-4-yl)ethyl]-1H...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0120 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita... | US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G | |||||||||||
More data for this Ligand-Target Pair |