BDBM35185 indazole-benzimidazole, 21

SMILES: CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(cc1)S(N)(=O)=O

InChI Key: InChIKey=ZNVPPIGJBRRFCD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 35185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM35185 (indazole-benzimidazole, 21) Show SMILES CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(cc1)S(N)(=O)=O Show InChI InChI=1S/C25H25N7O2S/c1-31-11-13-32(14-12-31)22-4-2-3-20-24(22)28-25(27-20)23-19-10-7-17(15-21(19)29-30-23)16-5-8-18(9-6-16)35(26,33)34/h2-10,15H,11-14H2,1H3,(H,27,28)(H,29,30)(H2,26,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.93E+3	n/a	n/a	n/a	n/a	7.5	23
Pfizer					Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...				Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H
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