BDBM352317 US10487086, Example I-136::US9802939, I-136
SMILES: Clc1ccc(c(\C=C\C(=O)N[C@H]2CCCCCNc3cc4[nH]ncc4cc3-c3c[nH]c2n3)c1)-n1cnnn1
InChI Key: InChIKey=OKTGZZNVPZFWRR-RFDUOBSXSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor XI (Homo sapiens (Human)) | BDBM352317 (US10487086, Example I-136 | US9802939, I-136) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 183 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm... | US Patent US10487086 (2019) BindingDB Entry DOI: 10.7270/Q2JD5069 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM352317 (US10487086, Example I-136 | US9802939, I-136) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 183 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake... | US Patent US9802939 (2017) BindingDB Entry DOI: 10.7270/Q2X63Q37 | |||||||||||
More data for this Ligand-Target Pair |