BDBM352431 N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl)-2-chloro-4-(1H-1,2,4-triazol-1-yl)benzamide ::US9808445, 8.1
SMILES: Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cncn1
InChI Key: InChIKey=ZRCDHFWLRCXXOX-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor IX (Homo sapiens (Human)) | BDBM352431 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent | Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ... | US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1 | |||||||||||
More data for this Ligand-Target Pair |