BDBM3530 6,7-dimethoxy-N-phenylquinazolin-4-amine::CHEMBL542484::CHEMBL94191::PD153035 Analog 29
SMILES: COc1cc2ncnc(Nc3ccccc3)c2cc1OC
InChI Key: InChIKey=MJKCGAHOCZLYDG-UHFFFAOYSA-N
Data: 13 IC50
PDB links: 5 PDB IDs contain this monomer as substructures. 5 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 39: 267-76 (1996) Article DOI: 10.1021/jm9503613 BindingDB Entry DOI: 10.7270/Q25T3HPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | 7.6 | 22 |
Hebrew University of Jerusalem | Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. | Bioorg Med Chem 4: 1203-7 (1996) Article DOI: 10.1016/0968-0896(96)00107-1 BindingDB Entry DOI: 10.7270/Q2BC3WR8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich Curated by ChEMBL | Assay Description Inhibition of EGFR | J Med Chem 51: 1179-88 (2008) Article DOI: 10.1021/jm070654j BindingDB Entry DOI: 10.7270/Q29Z95RD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Antagonism towards Colony stimulating factor 1 receptor (CSF-1R) | Bioorg Med Chem Lett 7: 421-424 (1997) Article DOI: 10.1016/S0960-894X(97)00035-8 BindingDB Entry DOI: 10.7270/Q2SB45RN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Antagonism towards Epidermal growth factor receptor | Bioorg Med Chem Lett 7: 421-424 (1997) Article DOI: 10.1016/S0960-894X(97)00035-8 BindingDB Entry DOI: 10.7270/Q2SB45RN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15... | Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Univ. Lille Nord de France Curated by ChEMBL | Assay Description Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting | J Med Chem 55: 1189-204 (2012) Article DOI: 10.1021/jm2013453 BindingDB Entry DOI: 10.7270/Q2086695 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of p56lck kinase autophosphorylation in Jurkat cells | Bioorg Med Chem Lett 7: 417-420 (1997) Article DOI: 10.1016/S0960-894X(97)00034-6 BindingDB Entry DOI: 10.7270/Q2J966VN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (RAT) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rajiv Gandhi Proudyogiki Vishwavidyalaya Curated by ChEMBL | Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate by scintillation counting in presence ... | Bioorg Med Chem 22: 1909-15 (2014) Article DOI: 10.1016/j.bmc.2014.01.044 BindingDB Entry DOI: 10.7270/Q26D5VHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rajiv Gandhi Proudyogiki Vishwavidyalaya Curated by ChEMBL | Assay Description inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATP | Bioorg Med Chem 22: 1909-15 (2014) Article DOI: 10.1016/j.bmc.2014.01.044 BindingDB Entry DOI: 10.7270/Q26D5VHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 201 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of EGFR (unknown origin) using biotinylated-PTP1B (Tyr66) as substrate incubated for 5 mins prior to substrate addition measured after 1 h... | Eur J Med Chem 61: 84-94 (2013) Article DOI: 10.1016/j.ejmech.2012.07.036 BindingDB Entry DOI: 10.7270/Q2X068CH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Univ. Lille Nord de France Curated by ChEMBL | Assay Description Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting | J Med Chem 55: 1189-204 (2012) Article DOI: 10.1021/jm2013453 BindingDB Entry DOI: 10.7270/Q2086695 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3530 (6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation. | Bioorg Med Chem Lett 7: 417-420 (1997) Article DOI: 10.1016/S0960-894X(97)00034-6 BindingDB Entry DOI: 10.7270/Q2J966VN | |||||||||||
More data for this Ligand-Target Pair |