BDBM354186 (R)-5-(2-(5-fluoro-2- methoxypyridin-3-yl)pyrrolidin-1- yl)-N-(3- hydroxypropyl)pyrazolo[l,5- a]pyrimidine-3-carboxamide::US9796724, Example 148

SMILES: COc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NCCCO)c2n1

InChI Key: InChIKey=VTUVGNKQBUVKIW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354186   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
JAK2 (aa 808-1132) (Homo sapiens (Human))	BDBM354186 ((R)-5-(2-(5-fluoro-2- methoxypyridin-3-yl)pyrrolid...) Show SMILES COc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NCCCO)c2n1 Show InChI InChI=1S/C20H23FN6O3/c1-30-20-14(10-13(21)11-23-20)16-4-2-7-26(16)17-5-8-27-18(25-17)15(12-24-27)19(29)22-6-3-9-28/h5,8,10-12,16,28H,2-4,6-7,9H2,1H3,(H,22,29)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM354186 ((R)-5-(2-(5-fluoro-2- methoxypyridin-3-yl)pyrrolid...) Show SMILES COc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NCCCO)c2n1 Show InChI InChI=1S/C20H23FN6O3/c1-30-20-14(10-13(21)11-23-20)16-4-2-7-26(16)17-5-8-27-18(25-17)15(12-24-27)19(29)22-6-3-9-28/h5,8,10-12,16,28H,2-4,6-7,9H2,1H3,(H,22,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair