BDBM356061 (S or R)-N-(6-((2,3- dihydroxypropanamido)methyl)- 2-phenylpyridin-3-yl)-2-fluoro- 5-(1-methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 61::US9815846, Compound 62

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2ccc(CNC(=O)C(O)CO)nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=YNIXJXCZVXVTOU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 356061   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356061 ((S or R)-N-(6-((2,3- dihydroxypropanamido)methyl)-...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2ccc(CNC(=O)C(O)CO)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C27H23F4N5O4/c1-36-10-9-21(35-36)17-11-18(20(28)12-19(17)27(29,30)31)25(39)34-22-8-7-16(13-32-26(40)23(38)14-37)33-24(22)15-5-3-2-4-6-15/h2-12,23,37-38H,13-14H2,1H3,(H,32,40)(H,34,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356061 ((S or R)-N-(6-((2,3- dihydroxypropanamido)methyl)-...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2ccc(CNC(=O)C(O)CO)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C27H23F4N5O4/c1-36-10-9-21(35-36)17-11-18(20(28)12-19(17)27(29,30)31)25(39)34-22-8-7-16(13-32-26(40)23(38)14-37)33-24(22)15-5-3-2-4-6-15/h2-12,23,37-38H,13-14H2,1H3,(H,32,40)(H,34,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair