BDBM356077 2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(2-((2- oxoimidazolidin-1-yl)methyl)-4- phenylpyrimidin-5-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 77

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3CCNC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=KAHBJSTXGJGOJC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356077   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356077 (2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(2-((2- o...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3CCNC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C26H21F4N7O2/c1-36-9-7-20(35-36)16-11-17(19(27)12-18(16)26(28,29)30)24(38)33-21-13-32-22(14-37-10-8-31-25(37)39)34-23(21)15-5-3-2-4-6-15/h2-7,9,11-13H,8,10,14H2,1H3,(H,31,39)(H,33,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair