BDBM356228 (R or S)-2-fluoro-N-(2-((5- (hydroxymethyl)-2- oxooxazolidin-3-yl)methyl)-4- phenylpyrimidin-5-yl)-5-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 228

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3CC(CO)OC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=HWPQUWCCLDGBPA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356228   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356228 ((R or S)-2-fluoro-N-(2-((5- (hydroxymethyl)-2- oxo...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3CC(CO)OC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C27H22F4N6O4/c1-36-8-7-21(35-36)17-9-18(20(28)10-19(17)27(29,30)31)25(39)33-22-11-32-23(13-37-12-16(14-38)41-26(37)40)34-24(22)15-5-3-2-4-6-15/h2-11,16,38H,12-14H2,1H3,(H,33,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair