BDBM357792 (4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- yl)-5,6-dihydro- [1,2,4]triazolo[4,3- a]pyrazin-7(8H)- yl)methanone::US10214533, Compound 2::US9969738, 2

SMILES: Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=UXOOGKCYBVVXAO-UHFFFAOYSA-N

Data: 7 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 357792   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuromedin-K receptor (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
OGEDA SA US Patent					Assay Description The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...				US Patent US10214533 (2019) BindingDB Entry DOI: 10.7270/Q21J9D35
					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description NK-2/NK-3: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 recep...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ
					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description NK-2/NK-3: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 recep...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description NK-1: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. ...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ
					More data for this Ligand-Target Pair
Substance-K receptor (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description NK-2/NK-3: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 recep...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
OGEDA SA US Patent					Assay Description The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membra...				US Patent US10214533 (2019) BindingDB Entry DOI: 10.7270/Q21J9D35
					More data for this Ligand-Target Pair
Substance-K receptor (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
OGEDA SA US Patent					Assay Description The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membra...				US Patent US10214533 (2019) BindingDB Entry DOI: 10.7270/Q21J9D35
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM357792 ((4-chlorophenyl)(3-(3- methyl-1,2,4-thiadiazol-5- ...) Show SMILES Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C15H13ClN6OS/c1-9-17-14(24-20-9)13-19-18-12-8-21(6-7-22(12)13)15(23)10-2-4-11(16)5-3-10/h2-5H,6-8H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
OGEDA SA US Patent					Assay Description The determination of plasma protein binding (PPB) of a compound is enabled by equilibrium dialysis, an accepted and standard method for reliable esti...				US Patent US10214533 (2019) BindingDB Entry DOI: 10.7270/Q21J9D35
					More data for this Ligand-Target Pair