null

SMILES: CCc1cncc(c1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC

InChI Key: InChIKey=JZKHWHWVLNGDPV-HNNXBMFYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360119   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM360119 ((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-pyrid...) Show SMILES CCc1cncc(c1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-9.66,6.43,;-8.12,6.43,;-7.35,5.1,;-8.12,3.77,;-7.35,2.43,;-5.81,2.43,;-5.04,3.77,;-5.81,5.1,;-3.5,3.77,;-3.02,2.3,;-1.48,2.3,;-1.01,3.77,;.32,4.54,;1.66,3.77,;.32,3,;2.99,3,;2.99,4.54,;2.99,6.08,;4.33,3.77,;5.66,4.54,;6.99,3.77,;8.33,4.54,;8.33,6.08,;9.66,6.85,;6.99,6.85,;5.66,6.08,;-2.25,4.67,;-2.25,6.21,;-3.59,6.98,;-4.92,6.21,;-6.26,6.98,;-3.59,8.52,;-2.25,9.29,;-.92,8.52,;-.92,6.98,;.41,6.21,;1.75,6.98,)| Show InChI InChI=1S/C24H26FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h6-8,10-15H,5,9H2,1-4H3,(H,30,31)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair