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SMILES: COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CC2)n1-c1c(OC)cccc1OC

InChI Key: InChIKey=WVGRJNWXPFOLPS-BVZFJXPGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360135   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM360135 ((1R,2R)-1-cyclopropyl-N-(4-(2,6-dimethoxyphenyl)-5...) Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CC2)n1-c1c(OC)cccc1OC |r,wD:22.23,24.25,(-18.17,-10.79,;-16.63,-10.95,;-15.73,-9.71,;-16.36,-8.3,;-15.45,-7.05,;-13.92,-7.21,;-13.29,-8.62,;-14.2,-9.87,;-11.76,-8.78,;-10.99,-10.12,;-9.48,-9.8,;-9.32,-8.26,;-7.99,-7.49,;-7.99,-5.95,;-6.66,-5.18,;-6.66,-3.64,;-5.32,-2.87,;-7.99,-2.87,;-6.66,-2.1,;-6.66,-8.26,;-5.89,-6.93,;-7.43,-9.6,;-5.32,-9.03,;-5.32,-10.57,;-3.99,-8.26,;-3.99,-6.72,;-2.66,-9.03,;-1.89,-10.37,;-1.12,-9.03,;-10.73,-7.64,;-11.05,-6.13,;-12.52,-5.66,;-13.66,-6.69,;-15.12,-6.21,;-12.84,-4.15,;-11.69,-3.12,;-10.23,-3.59,;-9.91,-5.1,;-8.44,-5.58,;-7.3,-4.55,)| Show InChI InChI=1S/C27H39N5O6SSi/c1-18(25(33)19-14-15-19)39(34,35)31(16-17-40(5,6)7)27-30-29-26(20-10-8-13-23(28-20)38-4)32(27)24-21(36-2)11-9-12-22(24)37-3/h8-13,18-19,25,33H,14-17H2,1-7H3/t18-,25-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair