BDBM360585 (R/S)-2-(6-methoxynaphthalen-2-yl)- N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)propanamide (mixture of 2 enantiomers)::US9828369, Example 142

SMILES: COc1cccc(c1)-c1ccc(CNC(=O)[C@H](C)c2ccc3cc(OC)ccc3c2)c2cnccc12

InChI Key: InChIKey=VNRCJGQSSGNHPY-HXUWFJFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360585   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360585 ((R/S)-2-(6-methoxynaphthalen-2-yl)- N-((5-(3-metho...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H](C)c2ccc3cc(OC)ccc3c2)c2cnccc12 |r| Show InChI InChI=1S/C31H28N2O3/c1-20(21-7-8-23-16-27(36-3)11-9-22(23)15-21)31(34)33-18-25-10-12-28(29-13-14-32-19-30(25)29)24-5-4-6-26(17-24)35-2/h4-17,19-20H,18H2,1-3H3,(H,33,34)/t20-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
					More data for this Ligand-Target Pair