BDBM360595 1-(2,3-dichlorophenyl)-3-((5-(3,5- dimethoxyphenyl)isoquinolin-8- yl)methyl)urea::US9828369, Example 152

SMILES: COc1cc(OC)cc(c1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12

InChI Key: InChIKey=GYISCEYLQYIQRR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360595   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360595 (1-(2,3-dichlorophenyl)-3-((5-(3,5- dimethoxyphenyl...) Show SMILES COc1cc(OC)cc(c1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12 Show InChI InChI=1S/C25H21Cl2N3O3/c1-32-17-10-16(11-18(12-17)33-2)19-7-6-15(21-14-28-9-8-20(19)21)13-29-25(31)30-23-5-3-4-22(26)24(23)27/h3-12,14H,13H2,1-2H3,(H2,29,30,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	198	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
					More data for this Ligand-Target Pair