BDBM361913 N-[(1S)-1-{[(cis)-2,6- dimethylmorpholin-4- yl]carbonyl}propyl]-9-ethyl-8-[6- (trifluoromethyl)pyridin-3-yl]- 9H-purin-6-amine::US10221178, Compound 2-7
SMILES: CC[C@H](Nc1ncnc2n(CC)c(nc12)-c1ccc(nc1)C(F)(F)F)C(=O)N1C[C@H](C)O[C@H](C)C1
InChI Key: InChIKey=AJMWOFZCSGEMSZ-LZWOXQAQSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM361913 (N-[(1S)-1-{[(cis)-2,6- dimethylmorpholin-4- yl]car...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Compounds are serially diluted (3-fold in 100% DMSO) across a 384-well polypropylene source plated from column 3 to column 12 and column 13 to column... | US Patent US10221178 (2019) BindingDB Entry DOI: 10.7270/Q20C4Z2D | |||||||||||
More data for this Ligand-Target Pair |