BDBM361946 N-{(1S)-1-cyclopropyl-2-[(cis)- 2,6-dimethylmorpholin-4-yl]-2- oxoethyl}-9-ethyl-8-(2- methylpyrimidin-5-yl)-9H-purin- 6-amine::US10221178, Compound 2-40

SMILES: CCn1c(nc2c(N[C@@H](C3CC3)C(=O)N3C[C@H](C)O[C@H](C)C3)ncnc12)-c1cnc(C)nc1

InChI Key: InChIKey=RMDOWQNUSKHSQS-IYOUNJFTSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361946   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM361946 (N-{(1S)-1-cyclopropyl-2-[(cis)- 2,6-dimethylmorpho...) Show SMILES CCn1c(nc2c(N[C@@H](C3CC3)C(=O)N3C[C@H](C)O[C@H](C)C3)ncnc12)-c1cnc(C)nc1 |r| Show InChI InChI=1S/C23H30N8O2/c1-5-31-21(17-8-24-15(4)25-9-17)29-19-20(26-12-27-22(19)31)28-18(16-6-7-16)23(32)30-10-13(2)33-14(3)11-30/h8-9,12-14,16,18H,5-7,10-11H2,1-4H3,(H,26,27,28)/t13-,14+,18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Compounds are serially diluted (3-fold in 100% DMSO) across a 384-well polypropylene source plated from column 3 to column 12 and column 13 to column...				US Patent US10221178 (2019) BindingDB Entry DOI: 10.7270/Q20C4Z2D
					More data for this Ligand-Target Pair