BDBM361955 N-[(1S)-1-{[(cis)-2,6- dimethylmorpholin-4- yl]carbonyl}-2-methylpropyl]-9- ethyl-8-(2-methylpyrimidin-5-yl)- 9H-purin-6-amine::US10221178, Compound 2-49

SMILES: CCn1c(nc2c(N[C@@H](C(C)C)C(=O)N3C[C@H](C)O[C@H](C)C3)ncnc12)-c1cnc(C)nc1

InChI Key: InChIKey=GFXSIGJYZMLGSM-DAYGRLMNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361955   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM361955 (N-[(1S)-1-{[(cis)-2,6- dimethylmorpholin-4- yl]car...) Show SMILES CCn1c(nc2c(N[C@@H](C(C)C)C(=O)N3C[C@H](C)O[C@H](C)C3)ncnc12)-c1cnc(C)nc1 |r| Show InChI InChI=1S/C23H32N8O2/c1-7-31-21(17-8-24-16(6)25-9-17)29-19-20(26-12-27-22(19)31)28-18(13(2)3)23(32)30-10-14(4)33-15(5)11-30/h8-9,12-15,18H,7,10-11H2,1-6H3,(H,26,27,28)/t14-,15+,18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Compounds are serially diluted (3-fold in 100% DMSO) across a 384-well polypropylene source plated from column 3 to column 12 and column 13 to column...				US Patent US10221178 (2019) BindingDB Entry DOI: 10.7270/Q20C4Z2D
					More data for this Ligand-Target Pair