BDBM362179 US10272077, Example 9 from U.S. Pat. No. 7,390,798::US9833448, Example 9 from U.S. Pat. No. 7,390,798

SMILES: Fc1cccc([C@@H]2CC[C@@H](NC(=O)c3ccc4CC5(Cc4c3)C(=O)Nc3ncccc53)C(=O)N(CC(F)(F)F)C2)c1F

InChI Key: InChIKey=SLMBMWIBJWYEMS-HZWJCNPPSA-N

Data: 2 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362179   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CGRP type 1 receptor (Homo sapiens (Human))	BDBM362179 (US10272077, Example 9 from U.S. Pat. No. 7,390,798...) Show SMILES Fc1cccc([C@@H]2CC[C@@H](NC(=O)c3ccc4CC5(Cc4c3)C(=O)Nc3ncccc53)C(=O)N(CC(F)(F)F)C2)c1F |r| Show InChI InChI=1S/C30H25F5N4O3/c31-22-5-1-3-20(24(22)32)18-8-9-23(27(41)39(14-18)15-30(33,34)35)37-26(40)16-6-7-17-12-29(13-19(17)11-16)21-4-2-10-36-25(21)38-28(29)42/h1-7,10-11,18,23H,8-9,12-15H2,(H,37,40)(H,36,38,42)/t18-,23-,29?/m1/s1	PDB GoogleScholar AffyNet	UniChem	US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q25X2C8C
					More data for this Ligand-Target Pair
Calcitonin receptor-like receptor (CLR) (Homo sapiens (Human))	BDBM362179 (US10272077, Example 9 from U.S. Pat. No. 7,390,798...) Show SMILES Fc1cccc([C@@H]2CC[C@@H](NC(=O)c3ccc4CC5(Cc4c3)C(=O)Nc3ncccc53)C(=O)N(CC(F)(F)F)C2)c1F |r| Show InChI InChI=1S/C30H25F5N4O3/c31-22-5-1-3-20(24(22)32)18-8-9-23(27(41)39(14-18)15-30(33,34)35)37-26(40)16-6-7-17-12-29(13-19(17)11-16)21-4-2-10-36-25(21)38-28(29)42/h1-7,10-11,18,23H,8-9,12-15H2,(H,37,40)(H,36,38,42)/t18-,23-,29?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem	US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...				US Patent US9833448 (2017) BindingDB Entry DOI: 10.7270/Q2BP052K
					More data for this Ligand-Target Pair