BDBM363473 (S)-9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-hydroxyethyl)- 4-(4-methyl-5-oxo-2,5- dihydrofuran-3-yl)-1-oxa-4,9- diazaspiro[5.5]undecan-5-one::US9850245, Example 6B

SMILES: CC1=C(COC1=O)N1CCOC2(CCN(C[C@@H](O)c3ccc(nc3)-n3cnnn3)CC2)C1=O

InChI Key: InChIKey=IILZZSPEHVYSAM-QGZVFWFLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363473   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-regulated potassium channel ROM-K (Homo sapiens (Human))	BDBM363473 ((S)-9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-hyd...) Show SMILES CC1=C(COC1=O)N1CCOC2(CCN(C[C@@H](O)c3ccc(nc3)-n3cnnn3)CC2)C1=O |r,t:1| Show InChI InChI=1S/C21H25N7O5/c1-14-16(12-32-19(14)30)27-8-9-33-21(20(27)31)4-6-26(7-5-21)11-17(29)15-2-3-18(22-10-15)28-13-23-24-25-28/h2-3,10,13,17,29H,4-9,11-12H2,1H3/t17-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...				US Patent US9850245 (2017) BindingDB Entry DOI: 10.7270/Q2H70J3N
					More data for this Ligand-Target Pair