BDBM363508 US9850257, Example 13

SMILES: Cc1noc(C)c1-c1cc(F)c2nnn3C(COc1c23)c1cccnc1

InChI Key: InChIKey=MPYHDTNRKVQYTD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 363508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [342-460] (Homo sapiens (Human))	BDBM363508 (US9850257, Example 13) Show SMILES Cc1noc(C)c1-c1cc(F)c2nnn3C(COc1c23)c1cccnc1 |(5.25,-2.42,;3.91,-3.19,;3.44,-4.65,;1.9,-4.65,;1.42,-3.19,;.09,-2.42,;2.67,-2.28,;2.67,-.74,;4,.03,;4,1.57,;5.33,2.34,;2.67,2.34,;2.12,3.83,;.54,3.83,;,2.34,;-1.33,1.57,;-1.33,.03,;,-.74,;1.33,.03,;1.33,1.57,;-2.67,2.34,;-4,1.57,;-5.33,2.34,;-5.33,3.88,;-4,4.65,;-2.67,3.88,)| Show InChI InChI=1S/C18H14FN5O2/c1-9-15(10(2)26-22-9)12-6-13(19)16-17-18(12)25-8-14(24(17)23-21-16)11-4-3-5-20-7-11/h3-7,14H,8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...				US Patent US9850257 (2017) BindingDB Entry DOI: 10.7270/Q2CF9SDT
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM363508 (US9850257, Example 13) Show SMILES Cc1noc(C)c1-c1cc(F)c2nnn3C(COc1c23)c1cccnc1 |(5.25,-2.42,;3.91,-3.19,;3.44,-4.65,;1.9,-4.65,;1.42,-3.19,;.09,-2.42,;2.67,-2.28,;2.67,-.74,;4,.03,;4,1.57,;5.33,2.34,;2.67,2.34,;2.12,3.83,;.54,3.83,;,2.34,;-1.33,1.57,;-1.33,.03,;,-.74,;1.33,.03,;1.33,1.57,;-2.67,2.34,;-4,1.57,;-5.33,2.34,;-5.33,3.88,;-4,4.65,;-2.67,3.88,)| Show InChI InChI=1S/C18H14FN5O2/c1-9-15(10(2)26-22-9)12-6-13(19)16-17-18(12)25-8-14(24(17)23-21-16)11-4-3-5-20-7-11/h3-7,14H,8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...				US Patent US9850257 (2017) BindingDB Entry DOI: 10.7270/Q2CF9SDT
					More data for this Ligand-Target Pair