BDBM364073 6-[3-fluoro-5-[(2-pyrrolidin-1-ylethylamino)methyl]phenyl]pyrido[3,2-d]pyrimidin-4-amine::US9855269, Compound 316

SMILES: Nc1ncnc2ccc(nc12)-c1cc(F)cc(CNCCN2CCCC2)c1

InChI Key: InChIKey=OQCTVSVCIYKZII-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364073   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM364073 (6-[3-fluoro-5-[(2-pyrrolidin-1-ylethylamino)methyl...) Show SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(CNCCN2CCCC2)c1 Show InChI InChI=1S/C20H23FN6/c21-16-10-14(12-23-5-8-27-6-1-2-7-27)9-15(11-16)17-3-4-18-19(26-17)20(22)25-13-24-18/h3-4,9-11,13,23H,1-2,5-8,12H2,(H2,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66.9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair