BDBM364079 6-[3-fluoro-5-[[(1-methylazetidin-3-yl)amino]methyl]phenyl]pyrido[3,2-d]pyrimidin-4-amine::US9855269, Compound 322

SMILES: CN1CC(C1)NCc1cc(F)cc(c1)-c1ccc2ncnc(N)c2n1

InChI Key: InChIKey=WVJZVNVHQJTDPS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364079   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM364079 (6-[3-fluoro-5-[[(1-methylazetidin-3-yl)amino]methy...) Show SMILES CN1CC(C1)NCc1cc(F)cc(c1)-c1ccc2ncnc(N)c2n1 Show InChI InChI=1S/C18H19FN6/c1-25-8-14(9-25)21-7-11-4-12(6-13(19)5-11)15-2-3-16-17(24-15)18(20)23-10-22-16/h2-6,10,14,21H,7-9H2,1H3,(H2,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair