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SMILES: COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(c4)C(F)(F)F)c3)cc(OC)cc2o1

InChI Key: InChIKey=NXJRNLXFFABWQC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364900   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364900
PNG
(US9862730, Example 358)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H22F3N3O5S/c1-36-21-11-24(22-13-26(40-25(22)12-21)23-14-35-27(33-23)41-28(34-35)37-2)39-16-18-6-4-8-20(10-18)38-15-17-5-3-7-19(9-17)29(30,31)32/h3-14H,15-16H2,1-2H3
UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.54n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...

J Med Chem 48: 6661-70 (2005)


BindingDB Entry DOI: 10.7270/Q2X92DKF
More data for this
Ligand-Target Pair