BDBM367653 N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-6-(4- fluorophenyl)-N-methyl-3,4- dihydroisoquinoline-1-carboxamide::US10227312, Example 39::US10759769, Example 39

SMILES: CN([C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1)C(=O)C1=NCCc2cc(ccc12)-c1ccc(F)cc1

InChI Key: InChIKey=WNEWPQABBJXDGK-QLWXXVCSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367653   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367653 (N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hy...) Show SMILES CN([C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1)C(=O)C1=NCCc2cc(ccc12)-c1ccc(F)cc1 |r,t:27| Show InChI InChI=1S/C33H35ClFN3O3/c1-37(33(40)31-27-12-6-22(18-23(27)14-15-36-31)21-4-8-25(35)9-5-21)29(20-38-16-2-3-17-38)32(39)24-7-13-30(28(34)19-24)41-26-10-11-26/h4-9,12-13,18-19,26,29,32,39H,2-3,10-11,14-17,20H2,1H3/t29-,32-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...				US Patent US10759769 (2020)
					More data for this Ligand-Target Pair
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367653 (N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hy...) Show SMILES CN([C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1)C(=O)C1=NCCc2cc(ccc12)-c1ccc(F)cc1 |r,t:27| Show InChI InChI=1S/C33H35ClFN3O3/c1-37(33(40)31-27-12-6-22(18-23(27)14-15-36-31)21-4-8-25(35)9-5-21)29(20-38-16-2-3-17-38)32(39)24-7-13-30(28(34)19-24)41-26-10-11-26/h4-9,12-13,18-19,26,29,32,39H,2-3,10-11,14-17,20H2,1H3/t29-,32-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...				J Med Chem 51: 1319-23 (2008) BindingDB Entry DOI: 10.7270/Q2G44SK0
					More data for this Ligand-Target Pair