BDBM367655 N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-6-(4- fluorophenyl)-3,3-dimethyl-3,4- dihydroisoquinoline-1-carboxamide::US10227312, Example 41::US10759769, Example 41

SMILES: CC1(C)Cc2cc(ccc2C(=N1)C(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1)-c1ccc(F)cc1

InChI Key: InChIKey=CUAGAHPSLRLAPY-QLWXXVCSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367655 (N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hy...) Show SMILES CC1(C)Cc2cc(ccc2C(=N1)C(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1)-c1ccc(F)cc1 |r,c:11| Show InChI InChI=1S/C34H37ClFN3O3/c1-34(2)19-24-17-22(21-5-9-25(36)10-6-21)7-13-27(24)31(38-34)33(41)37-29(20-39-15-3-4-16-39)32(40)23-8-14-30(28(35)18-23)42-26-11-12-26/h5-10,13-14,17-18,26,29,32,40H,3-4,11-12,15-16,19-20H2,1-2H3,(H,37,41)/t29-,32-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...				US Patent US10759769 (2020)
					More data for this Ligand-Target Pair
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367655 (N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hy...) Show SMILES CC1(C)Cc2cc(ccc2C(=N1)C(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1)-c1ccc(F)cc1 |r,c:11| Show InChI InChI=1S/C34H37ClFN3O3/c1-34(2)19-24-17-22(21-5-9-25(36)10-6-21)7-13-27(24)31(38-34)33(41)37-29(20-39-15-3-4-16-39)32(40)23-8-14-30(28(35)18-23)42-26-11-12-26/h5-10,13-14,17-18,26,29,32,40H,3-4,11-12,15-16,19-20H2,1-2H3,(H,37,41)/t29-,32-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...				J Med Chem 51: 1319-23 (2008) BindingDB Entry DOI: 10.7270/Q2G44SK0
					More data for this Ligand-Target Pair