BDBM368258 US10227338, Example 40::US10227338, Example 50

SMILES: CNC1CCN(C1)c1ccccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1

InChI Key: InChIKey=RFFZHBFJKYKHIB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368258   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM368258 (US10227338, Example 40 | US10227338, Example 50) Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C20H22ClN5O2S2/c1-22-14-8-9-26(11-14)19-5-3-2-4-18(19)24-17-7-6-15(10-16(17)21)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-14,22,24-25H,8-9,11H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...				J Med Chem 51: 1755-1763 (2008) BindingDB Entry DOI: 10.7270/Q2F47RFM
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM368258 (US10227338, Example 40 | US10227338, Example 50) Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C20H22ClN5O2S2/c1-22-14-8-9-26(11-14)19-5-3-2-4-18(19)24-17-7-6-15(10-16(17)21)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-14,22,24-25H,8-9,11H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...				J Med Chem 51: 1755-1763 (2008) BindingDB Entry DOI: 10.7270/Q2F47RFM
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM368258 (US10227338, Example 40 | US10227338, Example 50) Show SMILES CNC1CCN(C1)c1ccccc1Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C20H22ClN5O2S2/c1-22-14-8-9-26(11-14)19-5-3-2-4-18(19)24-17-7-6-15(10-16(17)21)30(27,28)25-20-12-29-13-23-20/h2-7,10,12-14,22,24-25H,8-9,11H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	328	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...				J Med Chem 51: 1755-1763 (2008) BindingDB Entry DOI: 10.7270/Q2F47RFM
					More data for this Ligand-Target Pair