BDBM3683 4-anilinopyrimido[5,4-d]pyrimidine deriv. 5b::6-Amino-4-[(3-bromophenyl)amino]pyrimido[5,4-d]pyrimidine::8-N-(3-bromophenyl)-[1,3]diazino[5,4-d]pyrimidine-2,8-diamine
SMILES: Nc1ncc2ncnc(Nc3cccc(Br)c3)c2n1
InChI Key: InChIKey=SJVLDEFAHRZRJJ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3683![]() (4-anilinopyrimido[5,4-d]pyrimidine deriv. 5b | 6-A...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich Curated by ChEMBL | Assay Description Inhibition of EGFR | J Med Chem 51: 1179-88 (2008) Article DOI: 10.1021/jm070654j BindingDB Entry DOI: 10.7270/Q29Z95RD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3683![]() (4-anilinopyrimido[5,4-d]pyrimidine deriv. 5b | 6-A...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8 | |||||||||||
More data for this Ligand-Target Pair |