null
SMILES: COc1cc(N(C)C[C@@H]2CCCN2C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-c1cn(C)c2ccccc12
InChI Key: InChIKey=MILBIPKHYWBIPY-QFIPXVFZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM368401![]() (US10227342, Example 35) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience | Assay Description A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic... | J Med Chem 51: 1730-9 (2008) BindingDB Entry DOI: 10.7270/Q21Z46Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM368401![]() (US10227342, Example 35) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience | Assay Description A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic... | J Med Chem 51: 1730-9 (2008) BindingDB Entry DOI: 10.7270/Q21Z46Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM368401![]() (US10227342, Example 35) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience | Assay Description A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,... | J Med Chem 51: 1730-9 (2008) BindingDB Entry DOI: 10.7270/Q21Z46Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human)) | BDBM368401![]() (US10227342, Example 35) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience | Assay Description A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l... | J Med Chem 51: 1730-9 (2008) BindingDB Entry DOI: 10.7270/Q21Z46Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [T790M] (Homo sapiens (Human)) | BDBM368401![]() (US10227342, Example 35) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience | Assay Description A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p... | J Med Chem 51: 1730-9 (2008) BindingDB Entry DOI: 10.7270/Q21Z46Q0 | |||||||||||
More data for this Ligand-Target Pair |