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SMILES: Cc1cc(C)n(n1)-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key: InChIKey=RAFVQPVOIRJYSQ-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368521   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM368521
PNG
(1-(3,5-dimethyl-1H- pyrazol-1-yl)-N- (1H-pyrazolo[...)
Show SMILES Cc1cc(C)n(n1)-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H17N7/c1-12-10-13(2)27(26-12)20-16-6-5-15(11-14(16)7-9-22-20)23-19-18-17(24-25-19)4-3-8-21-18/h3-11H,1-2H3,(H2,23,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 726n/an/an/an/a


TBA

Assay Description
Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl

Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM368521
PNG
(1-(3,5-dimethyl-1H- pyrazol-1-yl)-N- (1H-pyrazolo[...)
Show SMILES Cc1cc(C)n(n1)-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H17N7/c1-12-10-13(2)27(26-12)20-16-6-5-15(11-14(16)7-9-22-20)23-19-18-17(24-25-19)4-3-8-21-18/h3-11H,1-2H3,(H2,23,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 171n/an/an/an/a



Universita di Napoli



Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

J Med Chem 51: 1764-70 (2008)


BindingDB Entry DOI: 10.7270/Q2X63Q8G
More data for this
Ligand-Target Pair