BDBM368526 1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-3- yl)isoquinolin-6-amine::US10227343, Example 58

SMILES: FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key: InChIKey=RFPRBWBZNYJMKQ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 368526   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2X63Q8G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair