BDBM368537 1-(3,3-difluoropyrrolidin- 1-yl)-N-(1H- pyrazolo[4,3-b]pyridin- 3-yl)isoquinolin-6-amine::US10227343, Example 69

SMILES: FC1(F)CCN(C1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key: InChIKey=FIDMRJAYXPNROT-UHFFFAOYSA-N

Data: 2 EC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368537   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368537 (1-(3,3-difluoropyrrolidin- 1-yl)-N-(1H- pyrazolo[4...) Show SMILES FC1(F)CCN(C1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C19H16F2N6/c20-19(21)6-9-27(11-19)18-14-4-3-13(10-12(14)5-8-23-18)24-17-16-15(25-26-17)2-1-7-22-16/h1-5,7-8,10H,6,9,11H2,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	249	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl				Citation and Details
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368537 (1-(3,3-difluoropyrrolidin- 1-yl)-N-(1H- pyrazolo[4...) Show SMILES FC1(F)CCN(C1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C19H16F2N6/c20-19(21)6-9-27(11-19)18-14-4-3-13(10-12(14)5-8-23-18)24-17-16-15(25-26-17)2-1-7-22-16/h1-5,7-8,10H,6,9,11H2,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	249	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2X63Q8G
					More data for this Ligand-Target Pair