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SMILES: Fc1ccc(cc1)-c1cc2ncnc(-c3ccc(cc3)S(=O)(=O)NCc3ccccc3)c2s1

InChI Key: InChIKey=SNUQYNAKEIFPEF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 369319   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit [D816V]


(Homo sapiens (Human))		BDBM369319
PNG
(N-benzyl-4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimi...)
Show SMILES Fc1ccc(cc1)-c1cc2ncnc(-c3ccc(cc3)S(=O)(=O)NCc3ccccc3)c2s1
Show InChI InChI=1S/C25H18FN3O2S2/c26-20-10-6-18(7-11-20)23-14-22-25(32-23)24(28-16-27-22)19-8-12-21(13-9-19)33(30,31)29-15-17-4-2-1-3-5-17/h1-14,16,29H,15H2
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
 500n/an/an/an/an/an/an/an/a



Sapienza Universitāadi Roma



Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...

J Med Chem 51: 1560-76 (2008)


BindingDB Entry DOI: 10.7270/Q2HX1FZW
More data for this
Ligand-Target Pair