null

SMILES: Cc1cc(NC(=O)c2c(Cl)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1

InChI Key: InChIKey=RRKLCTZEISHUPD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 370369   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM370369 (US10233189, Example 75 | US10787457, Example 75 | ...) Show SMILES Cc1cc(NC(=O)c2c(Cl)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C15H16ClN7O/c1-7-5-8(22-21-7)20-14(24)9-10-12(17)18-6-19-13(10)23(11(9)16)15(2)3-4-15/h5-6H,3-4H2,1-2H3,(H2,17,18,19)(H2,20,21,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.150	n/a	n/a	n/a	n/a	n/a	n/a
Bayer HealthCare Pharmaceuticals Corporation					Assay Description To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...				J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2B85BDW
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM370369 (US10233189, Example 75 | US10787457, Example 75 | ...) Show SMILES Cc1cc(NC(=O)c2c(Cl)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C15H16ClN7O/c1-7-5-8(22-21-7)20-14(24)9-10-12(17)18-6-19-13(10)23(11(9)16)15(2)3-4-15/h5-6H,3-4H2,1-2H3,(H2,17,18,19)(H2,20,21,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154M86
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM370369 (US10233189, Example 75 | US10787457, Example 75 | ...) Show SMILES Cc1cc(NC(=O)c2c(Cl)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C15H16ClN7O/c1-7-5-8(22-21-7)20-14(24)9-10-12(17)18-6-19-13(10)23(11(9)16)15(2)3-4-15/h5-6H,3-4H2,1-2H3,(H2,17,18,19)(H2,20,21,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.150	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...				US Patent US10787457 (2020) BindingDB Entry DOI: 10.7270/Q2BR8W77
					More data for this Ligand-Target Pair