BDBM370400 US10233189, Example 85::US10787457, Example 85

SMILES: Cc1cc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1

InChI Key: InChIKey=KBHJOYQXMRWUFC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 370400   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM370400 (US10233189, Example 85 | US10787457, Example 85 | ...) Show SMILES Cc1cc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C22H25N7O2/c1-13-11-15(28-27-13)26-20(30)16-14(5-3-6-22(31)7-4-8-22)29(21(2)9-10-21)19-17(16)18(23)24-12-25-19/h11-12,31H,4,6-10H2,1-2H3,(H2,23,24,25)(H2,26,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Bayer HealthCare Pharmaceuticals Corporation					Assay Description To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...				J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2B85BDW
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM370400 (US10233189, Example 85 | US10787457, Example 85 | ...) Show SMILES Cc1cc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C22H25N7O2/c1-13-11-15(28-27-13)26-20(30)16-14(5-3-6-22(31)7-4-8-22)29(21(2)9-10-21)19-17(16)18(23)24-12-25-19/h11-12,31H,4,6-10H2,1-2H3,(H2,23,24,25)(H2,26,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...				US Patent US10787457 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM370400 (US10233189, Example 85 | US10787457, Example 85 | ...) Show SMILES Cc1cc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C22H25N7O2/c1-13-11-15(28-27-13)26-20(30)16-14(5-3-6-22(31)7-4-8-22)29(21(2)9-10-21)19-17(16)18(23)24-12-25-19/h11-12,31H,4,6-10H2,1-2H3,(H2,23,24,25)(H2,26,27,28,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM370400 (US10233189, Example 85 | US10787457, Example 85 | ...) Show SMILES Cc1cc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C22H25N7O2/c1-13-11-15(28-27-13)26-20(30)16-14(5-3-6-22(31)7-4-8-22)29(21(2)9-10-21)19-17(16)18(23)24-12-25-19/h11-12,31H,4,6-10H2,1-2H3,(H2,23,24,25)(H2,26,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM370400 (US10233189, Example 85 | US10787457, Example 85 | ...) Show SMILES Cc1cc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C22H25N7O2/c1-13-11-15(28-27-13)26-20(30)16-14(5-3-6-22(31)7-4-8-22)29(21(2)9-10-21)19-17(16)18(23)24-12-25-19/h11-12,31H,4,6-10H2,1-2H3,(H2,23,24,25)(H2,26,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM370400 (US10233189, Example 85 | US10787457, Example 85 | ...) Show SMILES Cc1cc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1 Show InChI InChI=1S/C22H25N7O2/c1-13-11-15(28-27-13)26-20(30)16-14(5-3-6-22(31)7-4-8-22)29(21(2)9-10-21)19-17(16)18(23)24-12-25-19/h11-12,31H,4,6-10H2,1-2H3,(H2,23,24,25)(H2,26,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...				US Patent US11014930 (2021)
					More data for this Ligand-Target Pair