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SMILES: [H][C@@]12C[C@H](C[C@]1([H])CN(CC(O)c1ccc(O)cn1)C2)Oc1c(F)cccc1F

InChI Key: InChIKey=OPSFITJHWYCWDS-HJGJULCPSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 370768   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1/2B


(Homo sapiens (Human))		BDBM370768
PNG
(US10239835, Example 00320)
Show SMILES [H][C@@]12C[C@H](C[C@]1([H])CN(CC(O)c1ccc(O)cn1)C2)Oc1c(F)cccc1F |r,w:10.11|
Show InChI InChI=1S/C20H22F2N2O3/c21-16-2-1-3-17(22)20(16)27-15-6-12-9-24(10-13(12)7-15)11-19(26)18-5-4-14(25)8-23-18/h1-5,8,12-13,15,19,25-26H,6-7,9-11H2/t12-,13+,15+,19?
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.60n/an/an/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Cell Culture and plating: HEK293 cells expressing NR1/NR2B (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...

J Med Chem 50: 984-1000 (2007)


BindingDB Entry DOI: 10.7270/Q2F19207
More data for this
Ligand-Target Pair