BDBM371293 N-(1-Cyanocyclopropyl)-1-[(3-methylisoxazol-5-yl)methyl]-3-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 400

SMILES: Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)o3)c2=O)S(=O)(=O)NC2(CC2)C#N)on1

InChI Key: InChIKey=GNFCKXREFIYWRD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371293   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
poly(ADP-ribose) glycohydrolase (PARG) (Homo sapiens (Human))	BDBM371293 (N-(1-Cyanocyclopropyl)-1-[(3-methylisoxazol-5-yl)m...) Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)o3)c2=O)S(=O)(=O)NC2(CC2)C#N)on1 Show InChI InChI=1S/C22H20N6O6S/c1-13-7-15(34-25-13)10-27-19-4-3-17(35(31,32)26-22(12-23)5-6-22)8-18(19)20(29)28(21(27)30)11-16-9-24-14(2)33-16/h3-4,7-9,26H,5-6,10-11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair