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SMILES: Cn1cc(Cn2c(=O)n(Cc3cnsc3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1

InChI Key: InChIKey=RSXUQECEUFEJGW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371468   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly(ADP-ribose) glycohydrolase


(Homo sapiens (Human))		BDBM371468
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-(isothiazol-4-yl...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3cnsc3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H21FN6O4S2/c1-26-9-14(7-23-26)10-28-19(29)17-6-16(34(31,32)25-21(13-22)4-5-21)2-3-18(17)27(20(28)30)11-15-8-24-33-12-15/h2-3,6-9,12,25H,4-5,10-11,13H2,1H3
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n/an/a 24n/an/an/an/an/an/a



Istituto Superiore di Sanita



Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...

J Med Chem 51: 1058-62 (2008)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair