BDBM371590 (R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl) chromane-7-sulfonamide::US10239869, Example 16

SMILES: Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F

InChI Key: InChIKey=LARCZEQUTRFGKA-GOSISDBHSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 371590   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 at resting state expressed in HEK293 cells at -120 mV holding potential by 10 Hz single pulse protocol based manual patch ...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Use-dependent inhibition of human Nav1.7 expressed in HEK293 cells at 25 pulse 10 Hz frequency at -120 mV holding potential by manual patch clamp ass...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of fast inactivation at 10 Hz frequency at -120 mV holding potential by single ...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Mus musculus)	BDBM371590 ((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...) Show SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H20F3N5O3S/c1-32-21(7-11-30-32)20-13-15(24(25,26)27)3-5-17(20)18-8-12-35-22-14-16(4-6-19(18)22)36(33,34)31-23-28-9-2-10-29-23/h2-7,9-11,13-14,18H,8,12H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20 mins follo...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair