BDBM371777 N-(5-fluoropyrimidin-2-yl)-4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)phenyl)chroman-7-sulfonamide::US10239869, Example 203

SMILES: Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncc(F)cn1)C(F)(F)F

InChI Key: InChIKey=NZKAKWZSTIGNFK-OAQYLSRUSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371777   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371777 (N-(5-fluoropyrimidin-2-yl)-4-(2-(6-methylpyridin-3...) Show SMILES Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncc(F)cn1)C(F)(F)F |r| Show InChI InChI=1S/C26H20F4N4O3S/c1-15-2-3-16(12-31-15)23-10-17(26(28,29)30)4-6-20(23)21-8-9-37-24-11-19(5-7-22(21)24)38(35,36)34-25-32-13-18(27)14-33-25/h2-7,10-14,21H,8-9H2,1H3,(H,32,33,34)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371777 (N-(5-fluoropyrimidin-2-yl)-4-(2-(6-methylpyridin-3...) Show SMILES Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncc(F)cn1)C(F)(F)F |r| Show InChI InChI=1S/C26H20F4N4O3S/c1-15-2-3-16(12-31-15)23-10-17(26(28,29)30)4-6-20(23)21-8-9-37-24-11-19(5-7-22(21)24)38(35,36)34-25-32-13-18(27)14-33-25/h2-7,10-14,21H,8-9H2,1H3,(H,32,33,34)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM371777 (N-(5-fluoropyrimidin-2-yl)-4-(2-(6-methylpyridin-3...) Show SMILES Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncc(F)cn1)C(F)(F)F |r| Show InChI InChI=1S/C26H20F4N4O3S/c1-15-2-3-16(12-31-15)23-10-17(26(28,29)30)4-6-20(23)21-8-9-37-24-11-19(5-7-22(21)24)38(35,36)34-25-32-13-18(27)14-33-25/h2-7,10-14,21H,8-9H2,1H3,(H,32,33,34)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair