BDBM374620 Ethyl 6-([1,4′-bipiperidin]-1′-yl)-1-(1-(2,4-dichlorophenyl)ethyl)-1H-pyrazolo[3,4-b]pyrazine-3-carboxylate hydrochloride::US10246462, Example 1

SMILES: CCOC(=O)c1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(cnc12)N1CCC(CC1)N1CCCCC1

InChI Key: InChIKey=ZALFJDIUVKCSGF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374620   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374620 (Ethyl 6-([1,4′-bipiperidin]-1′-yl)-1-(...) Show SMILES CCOC(=O)c1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(cnc12)N1CCC(CC1)N1CCCCC1 Show InChI InChI=1S/C26H32Cl2N6O2/c1-3-36-26(35)24-23-25(34(31-24)17(2)20-8-7-18(27)15-21(20)28)30-22(16-29-23)33-13-9-19(10-14-33)32-11-5-4-6-12-32/h7-8,15-17,19H,3-6,9-14H2,1-2H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13
					More data for this Ligand-Target Pair