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SMILES: Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccc(F)c2)cc1

InChI Key: InChIKey=KVAWTIAIESZLOU-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374852   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Wnt-3a


(Homo sapiens (Human))		BDBM374852
PNG
(US10251893, Cpd 56)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccc(F)c2)cc1
Show InChI InChI=1S/C25H20FN3O/c1-17-13-21(11-12-27-17)19-7-5-18(6-8-19)14-25(30)29-24-10-9-22(16-28-24)20-3-2-4-23(26)15-20/h2-13,15-16H,14H2,1H3,(H,28,29,30)
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US Patent
n/an/a<0.0900n/an/an/an/an/an/a



St. Jude Research Hospital



Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...

J Med Chem 50: 5727-34 (2007)


BindingDB Entry DOI: 10.7270/Q2GM89KJ
More data for this
Ligand-Target Pair