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SMILES: Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC(F)(F)F)c2n1

InChI Key: InChIKey=IESPWTFFLPDHJL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM374927 ((R)-5-(2-(5-fluoropyridin-3- yl)pyrrolidin-1-yl)-N...) Show SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC(F)(F)F)c2n1 Show InChI InChI=1S/C18H16F4N6O/c19-12-6-11(7-23-8-12)14-2-1-4-27(14)15-3-5-28-16(26-15)13(9-25-28)17(29)24-10-18(20,21)22/h3,5-9,14H,1-2,4,10H2,(H,24,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM374927 ((R)-5-(2-(5-fluoropyridin-3- yl)pyrrolidin-1-yl)-N...) Show SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC(F)(F)F)c2n1 Show InChI InChI=1S/C18H16F4N6O/c19-12-6-11(7-23-8-12)14-2-1-4-27(14)15-3-5-28-16(26-15)13(9-25-28)17(29)24-10-18(20,21)22/h3,5-9,14H,1-2,4,10H2,(H,24,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair